Innate immunity to mycobacteria: Vitamin D and autophagy

77Citations
Citations of this article
137Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Summary: Autophagy is an ancient mechanism of protein degradation and a novel antimicrobial strategy. With respect to host defences against mycobacteria, autophagy plays a crucial role in antimycobacterial resistance, and contributes to immune surveillance of intracellular pathogens and vaccine efficacy. Vitamin D3 contributes to host immune responses against Mycobacterium tuberculosis through LL-37/hCAP-18, which is the only cathelicidin identified to date in humans. In this review, we discuss recent advances in our understanding of host immune strategies against mycobacteria, including vitamin D-mediated innate immunity and autophagy activation. This review also addresses our current understanding regarding the autophagy connection to principal innate machinery, such as ubiquitin- or inflammasome-involved pathways. Integrated dialog between autophagy and innate immunity may contribute to adequate host immune defences against mycobacterial infection. © 2010 Blackwell Publishing Ltd.

Cite

CITATION STYLE

APA

Jo, E. K. (2010, August). Innate immunity to mycobacteria: Vitamin D and autophagy. Cellular Microbiology. https://doi.org/10.1111/j.1462-5822.2010.01491.x

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free