Ultrafiltration for patients with acute decompensated heart failure A systematic review and meta-analysis

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Abstract

Background: Ultrafiltration plays an indispensable role in relieving congestion and fluid retention in patients with acute decompensated heart failure (ADHF) in recent years. So far, there is no consistent agreement about whether early ultrafiltration (UF) is a first-line treatment for patients with ADHF. We, therefore, conducted a meta-analysis to assess the efficacy and safety of UF. Methods: PubMed, Embase, and Cochrane Library databases were searched for randomized controlled trials (RCTs) that compared UF with diuretics in patients with ADHF and included our interested outcomes. The primary outcomes are heart failure rehospitalization, all-cause rehospitalization, and mortality. The second outcomes are fluid loss, weight loss, and adverse events. RevMan Version 5.4.1 was used to analyze the data of included studies. Results:A total of 12 studies with 1197 patients were included. Our results showed a reduction in heart failure rehospitalization (risk ratio [RR] 0.67, 95% confidence interval [CI]: 0.52-0.87, P=.003) and all-cause rehospitalization (RR 0.62, 95% CI: 0.42-0.92; P=.02), an increase in fluid loss (1.47 L, 95% CI: 0.95-1.99 L, P

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Wang, M. J., Zheng, Y. M., & Jin, H. X. (2021, December 17). Ultrafiltration for patients with acute decompensated heart failure A systematic review and meta-analysis. Medicine (United States). Lippincott Williams and Wilkins. https://doi.org/10.1097/MD.0000000000028029

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