Stressed-out yeast do not pass GO

Abstract

Using microfluidics and imaging, Argüello-Miranda et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202103171) monitor the response of individual yeast cells to nutrient withdrawal. They discover that cells arrest not only in the early G1 phase as expected, but also later in the cell cycle, and that Xbp1 is critical for arrest at other cell cycle phases.