Propofol abuse

Abstract

Propofol (2,6-diisopropylphenol), an intravenous anesthetic agent used for the rapid induction of general anesthesia and for moderate to deep sedation for painful or uncomfortable procedures, was not considered by most health-care workers as a likely drug for recreational use despite a significant potential for abuse. Nonmedical use was, at least until recently, primarily by medical professionals. It is not classified yet as a controlled substance by the United States Drug Enforcement Agency, which might suggest little potential for drug abuse although the status may change soon as the DEA is circulating a proposed rule that would classify propofol as a Schedule 1V substance putting it in the same category as the benzodiazepines and zolpidem. Fospropofol, (Lusedra®, Eisai) a drug similar to propofol was added to the Schedule in 2009. To date, (October 2010) the drug is freely available in the hospital setting, including operating and emergency rooms, critical care areas, and especially in endoscopy suites and outpatient facilities.