AIDS-related malignant lymphoma

Abstract

Patients with HIV-1 infection have high risk for malignant lymphoma(AIDS lymphoma). In Japanese patients, more than 90% of AIDS lymphoma are related to EBV. All 22 cases which we have experienced are non-Hodgkin's lymphoma and their histological classification is either diffuse large or diffuse immunoblastic. Their mean CD4 count is 13.6/mm3. The reports from United States and Europe show that a half of AIDS lymphoma cases are small noncleaved type and the mean CD4 count is approximately 200/mm3. This difference between Japan and other countries may be caused by difference of EBV prevalence, but precise reason is not clear.