Retrospektive Analyse von Tuberkuloseerkrankungen durch Mycobacterium bovis 2004-2008

Abstract

Background: Mycobacterium bovis is a rare cause of tuberculosis in Germany. Epidemiological data are sparse. Methods: We have carried out a retrospective analysis of all patients diagnosed with tuberculosis caused by M. bovis in a pneumological referral centre between 2004 and 2008. Results: M. bovis was isolated in 8 out of 203 (3,9%) patients with a new diagnosis of tuberculosis. The median age of these patients was 69 years, and 7 out of 8 showed risk factors for reactivation of a latent tuberculosis infection. In 4 patients (50%) an extrapulmonary manifestation was present. All isolates of M. bovis were resistant to pyrazinamide, one isolate had an additional resistance to isoniazide. In 6 out of 8 patients prolonged tuberculostatic treatment of 812 months was recommended. Conclusions: The proportion of tuberculosis caused by M. bovis was higher than that reported for Germany (3.9 vs. 1,5%). Predominantly elderly patients with risk factors for reactivation of a latent tuberculosis infection were affected. In accordance with the literature a high rate of extrapulmonary manifestations was detected. Because of the genetic resistance of M. bovis to pyrazinamide prolonged antimycobacterial treatment is recommended. © 2010 Georg Thieme Verlag KG Stuttgart · New York.