Ensemble of Algorithms for Multifocal Cervical Cell Image Segmentation

Abstract

One of the main challenges for cell segmentation is to separate overlapping cells, which is also a challenging task for cytologists. Here we propose a method that combines different algorithms for cervical cell segmentation of Pap smear images and searches for the best result underlying the maximization of a similarity coefficient. We carried out experiments with three state-of-the-art segmentation algorithms on images with clumps of cervical cells. We extracted features such as coefficient of variation and overlapping ratios for each cell grouping and selected the most appropriate algorithm to segment each cell clump. For decision criterion, we identified the cell clumps of the training dataset and calculated the mentioned features. We segmented each clump by the algorithms and reckoned the Dice measure from each segmentation. Finally, we used the kNN classifier to predict the best algorithm among neighboring k-clumps by choosing the one with the largest number of wins. We validated our proposal on multifocal cervical cell images and obtained an average Dice around 76.6% without using a threshold value. These results demonstrated that the proposed ensemble of segmentation algorithms is promising and suitable for cervical cell image segmentation.