Anti-inflammatory and antidiabetic activity of ethanolic extracts of Sterculia villosa barks on albino wistar rats

Abstract

Ethanolic extract of Sterculia villosa barks were studied for anti-inflammatory and antidiabetic activity. The acute oral toxicity showed that the ethanolic extract of S. villosa barks was safe until 4000mg/kg body weight and no macroscopical organ abnormalities were observed in acute oral models. The investigations on Albino (Wistar) rats at dosage of 100, 200 and 400 mg/kg of ethanolic extract of Sterculia villosa barks were made for aniti-inflammatory action by using carrageenan induced paw edema and cotton pellete granuloma technique. The results of the study suggested significant do se dependent activity of extracts as compared to control group for both acute and chronic inflam mation. Ethanolic extract also showed significant antidiabetic activity at dose dependent man ner compared to diabetic untreated group.