Synthesis of new 1,2,3-triazol-4-yl-quinazoline nucleoside and acyclonucleoside analogues

Abstract

In this study, we describe the synthesis of 1,4-disustituted-1,2,3- triazoloquinazoline ribonucleosides or acyclonucleosides by means of 1,3-dipolar cycloaddition between various O or N-Alkylated propargyl-quinazoline and 1'-Azido-2',3',5'-tri-Obenzoylribose or activated alkylating agents under microwave conditions. None of the compounds selected showed significant anti-HCV activity in vitro. © 2014 by the authors; licensee MDPI, Basel, Switzerland.