Comparison of 0.2 Mg/kg Vs. 1.0 Mg/kg of Oral Meloxicam for Safe and Effective Analgesia in Domestic Rabbits

Abstract

PICO question In domestic rabbits, how does 1 mg/kg of oral meloxicam compare with 0.2 mg/kg of oral meloxicam for significant changes in pain behaviour, and kidney and liver biochemical analytes? Clinical bottom line Based on current available evidence, oral meloxicam at a dosage of 0.2 mg/kg daily when used as the sole analgesic does not provide adequate pain relief in rabbits. A dosage of 1 mg/kg daily is more efficacious, but it is unclear whether this is sufficient for postoperative pain management. The literature supports the safety of meloxicam at both 0.2 mg/kg and 1 mg/kg daily for healthy rabbits, based on liver and kidney biochemical analytes. Five studies have been reviewed, which are a mix of randomised controlled trials and prospective clinical trials.