Antibacterial multi-layered nanocellulose-based patches loaded with dexpanthenol for wound healing applications

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Abstract

Antibacterial multi-layered patches composed of an oxidized bacterial cellulose (OBC) membrane loaded with dexpanthenol (DEX) and coated with several chitosan (CH) and alginate (ALG) layers were fabricated by spin-assisted layer-by-layer (LbL) assembly. Four patches with a distinct number of layers (5, 11, 17, and 21) were prepared. These nanostructured multi-layered patches reveal a thermal stability up to 200 °C, high mechanical performance (Young’s modulus ≥ 4 GPa), and good moisture-uptake capacity (240–250%). Moreover, they inhibited the growth of the skin pathogen Staphylococcus aureus (3.2–log CFU mL−1 reduction) and were non-cytotoxic to human keratinocytes (HaCaT cells). The in vitro release profile of DEX was prolonged with the increasing number of layers, and the time-dependent data imply a diffusion/swelling-controlled drug release mechanism. In addition, the in vitro wound healing assay demonstrated a good cell migration capacity, headed to a complete gap closure after 24 h. These results certify the potential of these multi-layered polysaccharides-based patches toward their application in wound healing.

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Fonseca, D. F. S., Carvalho, J. P. F., Bastos, V., Oliveira, H., Moreirinha, C., Almeida, A., … Freire, C. S. R. (2020). Antibacterial multi-layered nanocellulose-based patches loaded with dexpanthenol for wound healing applications. Nanomaterials, 10(12), 1–16. https://doi.org/10.3390/nano10122469

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