The COMT Val158Met polymorphism has recently been identified as a predictor for cognitive decline in Parkinson’s disease (PD). However, it remains unknown whether an early brain structural compromise could be involved in this clinical association. Here, in a cohort of 120 cognitively preserved de novo PD patients from the Parkinson’s Progression Markers Initiative (PPMI) database, we found a widespread reduction in cerebral gray matter volume (GMV) in patients harboring the Val/Val genotype. The atrophic pattern included fronto-subcortical and parieto-temporal territories. Importantly, the GMV at some of the identified regions was associated with cognitive decline in a 4-year follow-up period. These findings suggest that GMV compromise in the early stages of PD may be a predisposing factor for cognitive decline of COMT Val/Val homozygotes.
CITATION STYLE
Sampedro, F., Marín-Lahoz, J., Martínez-Horta, S., Pagonabarraga, J., & Kulisevsky, J. (2020). Reduced gray matter volume in cognitively preserved COMT 158Val/Val Parkinson’s disease patients and its association with cognitive decline. Brain Imaging and Behavior, 14(2), 321–328. https://doi.org/10.1007/s11682-018-0022-y
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