Preshearing is an in situ setting modification method for inorganic bone cements

Abstract

The flow behaviour and injectability of calcium phosphate cements are outcomes of the complex interplay between time‐dependent processes of dissolution, nucleation and crystal growth. Their dependence on shear strains, frequencies and rates has been revealed by rheological investigation of the setting processes of a brushite cement under torsional flow. Various oscillatory torsional strain amplitudes and frequencies were seen to promote dissolution or delay crystal intergrowth compared to quiescently set cement samples. Oscillatory torsional strain amplitudes higher than the linear viscoelastic strain limit resulted in a pronounced lag in crystal intergrowth. Dissolution was enhanced and setting was promoted with increasing frequency and strain amplitude within the linear viscoelastic strain range. Changing the preshearing mode to steady torsion increased energy spent to microstructural deformation, counteracting the beneficial vibratory effect on cement setting kinetics, and produced a net retardation by the disruption of the crystal network structure. Such deformation history can be created in the cement suspension prior to injection during clinical practice by precise adjustment of the preshearing modes and parameters to enable the orthopaedic surgeon tailor the setting time, flow behaviour and injectability of calcium phosphate cements in situ without altering the cement chemistry, hence bioactivity.