Myosin regulatory light chain (RLC) phosphorylation change as a modulator of cardiac muscle contraction in disease

Abstract

Background: Cardiac myosin regulatory light chain (RLC) phosphorylation alters cardiac muscle function. Results: Phosphorylation affects mechanical parameters of cardiac muscle contraction during shortening. Conclusion: Phosphorylation impacts mechanical function of cardiac muscle and is altered during cardiac disease. Significance: Understanding RLC regulation by phosphorylation in cardiac muscle contraction is crucial for understanding changes in disease. Copyright © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.