A case report and focused literature review of d-penicillamine and severe neutropenia: A serious toxicity from a seldom-used drug

Abstract

Prescribing d-penicillamine for Wilson's disease must be accompanied by vigilant monitoring, including a complete blood cell count with differential. For most, this should occur once or twice weekly during the first month of therapy and during periods of dose escalation, then every two weeks for six additional months, then monthly.