In Vitro Antioxidant and Cancer Inhibitory Activity of a Colored Avocado Seed Extract

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Abstract

Avocado (Persea americana) seeds have been used traditionally for a number of health-related indications. Because of its high polyphenol content, we investigated the potential antioxidant and anticancer effects of a colored avocado seed extract (CASE). CASE exhibited an oxygen radical acceptance capacity value of 2012 ± 300 trolox equivalents/mg. CASE reduced lipid hydroperoxide formation in an oil-in-water emulsion (33% reduction at 500 μg/mL). CASE dose-dependently reduced the viability of human breast (MCF7), lung (H1299), colon (HT29), and prostate (LNCaP) cancer cells in vitro. The half maximal inhibitory concentrations ranged from 19 to 132 μg/mL after treatment for 48 h. CASE treatment downregulated the expression of cyclin D 1 and E 2 in LNCaP cells. This was associated with cell G 0 /G 1 phase cycle arrest. CASE also dose-dependently induced apoptosis in LNCaP cells. CASE reduced nuclear translocation of nuclear factor B, a prosurvival signal. Further studies are needed to examine these effects in in vivo models.

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Dabas, D., Elias, R. J., Ziegler, G. R., & Lambert, J. D. (2019). In Vitro Antioxidant and Cancer Inhibitory Activity of a Colored Avocado Seed Extract. International Journal of Food Science, 2019. https://doi.org/10.1155/2019/6509421

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