Association of platelet integrin αiibβ3 polymorphisms with atherosclerotic coronary heart disease in sudanese patients

Abstract

Background and Objective: Glycoprotein IIIa and GPIIb constitutes are the fibrinogen receptor (integrin αIIbβ3). This glycoprotein has a fundamental role in atherothrombosis. This study aimed to detect the association of αIIbβ3 polymorphisms with atherosclerotic coronary heart disease in Sudanese patients and the association between the risk factors and platelet integrin αIIbβ3 polymorphisms. Materials and Methods: This is a case-control hospital-based study contain 50 atherosclerotic patients (>18 years) with coronary heart disease that admitted to Khartoum hospital and were compared to apparently 50 healthy Sudanese subjects at the same ages. About 5 mL of venous blood sample was collected from each patient and control. The laboratory analyses were done for HbA1c, lipid profile and for DNA genotyping. Results: LDL, HDL, HbA1c and body mass index have shown highly significant influence on patients. No significant differences were observed for triglycerides and total cholesterol levels. The risks of coronary heart disease were higher with A/B genotype in HPA3, but no association detected with coronary heart disease patients in HPA1 polymorphism. Conclusion: In conclusion, HPA3 polymorphism was associated with atherosclerotic in Sudanese patients, while HPA1 polymorphism has not.