Study role of interleukin 23 level, family histories and blood groups in psoriasis patients

Abstract

Background: Psoriasis is the one of important autoimmune diseases with chronic inflammatory signs in skin Erythematous, scaly plaques, and can infect all ages and in all countries. Objectives & Methodology: In order to detect the incidence of Psoriasis and its association with elevated IL-23, 70 people were involved in the current study, their ages were (1-45) years and from both genders 30 of them was with Psoriasis and the family history groups 20 and the other healthy 20 were cosidered as control groups . This study was worked in the central health laboratory, Hilla Teaching Hospital in the peroid Nov.2018 to Feb.2019 in Babylon Governorate. Results: the IL-23 of in Psoriasis patients has a significant with same results in family history groups in all age groups when comparison with control group. The results also showed that patients of blood group (O+) are the most frequent by percent (33.33) followed by B+, A+, AB+ and AB¯ with percent reached (30%,20%,10% and 6. 67%) respectively. Furthermore, there is a genetic tendency in the frequency of onset of Psoriasis as 20% in both parents and (30&10 %) in mothers and fathers respectively while 40% of the disease does not appear in their families. Results also showed significant increasing in the age groups (31-45) years in comparison with (1-15) and (16-30) years. The disease also rises in males compared with females. Conclusions: a significant increase in IL-23for patients with Psoriasis compared with the control group. Patients with family history are at high risk to develop Psoriasis. The age group (31–45) found to have high incidence of Psoriasis compared with other age groups. Persons of O+ blood groups may be at high risk to have Psoriasis.