This review examines the proposition that the nucleosome, in addition to its role as a DNA packaging device, is a signaling module through which changing environmental and metabolic conditions can influence genomic functions. The role of enzyme-catalyzed post-translational modifications of the core histones is critically assessed, leading to the conclusion that they play varied, often crucial and sometimes causative roles in this signaling process. © 2012 Elsevier Ltd.
CITATION STYLE
Turner, B. M. (2012, September). The adjustable nucleosome: An epigenetic signaling module. Trends in Genetics. https://doi.org/10.1016/j.tig.2012.04.003
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