The Research Progress of Vascular Aging Related Diseases

Abstract

The aging-related factors of population, environment, physical inactivity and unhealthy diet have emerged as significant contributors to the onset of vascular aging, which poses a crucial risk for various diseases including hypertension, coronary heart disease, heart failure and stroke. The structural, phenotypic, and functional changes in vasculature resulting from aging are critical in the pathogenesis of vascular aging-related diseases. Numerous molecular and cellular phenomena, including oxidative stress, mitochondrial dysfunction, vascular inflammation, cellular senescence, and epigenetic alterations, are closely linked to the pathophysiology of vascular aging. Given the escalating hospitalization rates attributed to vascular aging-related illness, the need for efficacious interventions to counteract the decline in vascular function is becoming increasingly pressing. This review provides an overview of recent developments in vascular aging-related disorders, encompassing cardiovascular diseases, neurodegenerative diseases, chronic kidney diseases, and sarcopenia. Furthermore, a comprehensive examination of the pathogenesis of aging is conducted, and the implementation of intervention strategies (including drug and lifestyle interventions) can effectively mitigate the onset and progression of aging-related ailments, thereby facilitating the achievement of healthy aging and longevity.