Hypnotic and opioid anesthetic drug interactions on the CNS, focus on response surface modeling

Abstract

This chapter will present the conceptual and applied approaches to capture the interaction of anesthetic hypnotic drugs with opioid drugs, as used in the clinical anesthetic state. The graphic and mathematical approaches used to capture hypnotic/opiate anesthetic drug interactions will be presented. This chapter is not a review article about interaction modeling, but focuses on specific drug interactions within a quite narrow field, anesthesia. © 2008 Springer-Verlag Berlin Heidelberg.