Skip to content

The STIM-orai pathway: Orai, the pore-forming subunit of the CRAC channel

N/ACitations
Citations of this article
17Readers
Mendeley users who have this article in their library.
Get full text

Abstract

This chapter focuses on the Orai proteins, Orai1–Orai3, with special emphasis on Orai1, in humans and other mammals, and on the definitive evidence that Orai is the pore subunit of the CRAC channel. It begins by reviewing briefly the defining characteristics of the CRAC channel, then discusses the studies that implicated Orai as part of the store-operated Ca2+ entry pathway and as the CRAC channel pore subunit, and finally examines ongoing work that is providing insights into CRAC channel structure and gating.

Cite

CITATION STYLE

APA

Gudlur, A., & Hogan, P. G. (2017). The STIM-orai pathway: Orai, the pore-forming subunit of the CRAC channel. In Advances in Experimental Medicine and Biology (Vol. 993, pp. 39–57). Springer New York LLC. https://doi.org/10.1007/978-3-319-57732-6_3

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free