DLK1-DIO3 represents an imprinted cluster which genes are involved in physiological cell biology as early as the stem cell level and in the pathogenesis of several diseases. Transcription factor-mediated induced pluripotent cells (iPSCs) are considered an unlimited source of patient-specific hematopoietic stem cells for clinical application in patient-tailored regenerative medicine. However, to date there is no marker established able to distinguish embryonic stem cell-equivalent iPSCs or safe human iPSCs. Recent findings suggest that the DLK1-DIO3 locus possesses the potential to represent such a marker but there are also contradictory data. This review aims to report the current data on the topic describing both sides of the coin.
CITATION STYLE
Benetatos, L., Vartholomatos, G., & Hatzimichael, E. (2014, October 24). DLK1-DIO3 imprinted cluster in induced pluripotency: Landscape in the mist. Cellular and Molecular Life Sciences. Birkhauser Verlag AG. https://doi.org/10.1007/s00018-014-1698-9
Mendeley helps you to discover research relevant for your work.