Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM

Abstract

Background: Leukocyte adhesion to arterial endothelial cells is thought to be an important step in the development of atherosclerosis, Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) and the endothelial-leukocyte adhesion molecule-1 (ELAM-1) play an essential role in the early stages of atherogenesis of diabetic patients. Materials and Methods: The study was conducted on 80 male divided into two groups 60 of them had diabetes mellitus and 20 subjects were normal healthy individuals served as a control group. Enzyme linked immune sorbent assay (ELISA) was used for the measurement of serum VCAM-1and ELAM-1and WBC assay executed by automatic hematology analyzer the information of patients were obtained through a questionnaire consisted Patients with other diseases were excluded from the current investigation. Results: This result revealed elevated level of serum VCAM-1and ELAM-1 of Diabetes patients compared with healthy group also differentiation count reveal elevated count of WBC, Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil in Diabetes patient as compare with HT group.