Abstract
Cancer-associated fibroblasts undergo the reverse Warburg effect and provide cancer cells with glycolytic metabolites.The interaction between cancer cells and CAFs helps cancer cells manage the Warburg effect.Loss of stromal Cav-1 is a biomarker of poor prognosis in breast cancers.CAF-derived exosomes (CDE) can reprogram the metabolic pathway of cancer cells.CAFs augment cancer addiction to glutamine and its metabolically-relevant consequences.Alanine secreted by pancreatic stellate cells supports tumor metabolism.
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Sazeides, C., & Le, A. (2018). Metabolic relationship between cancer-associated fibroblasts and cancer cells. In Advances in Experimental Medicine and Biology (Vol. 1063, pp. 149–165). Springer New York LLC. https://doi.org/10.1007/978-3-319-77736-8_11
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