The usage of ACCLUSTER for peptide binding site prediction

Abstract

Peptides mediate up to 40 % of protein–protein interactions in a variety of cellular processes and are also attractive drug candidates. Thus, predicting peptide binding sites on the given protein structure is of great importance for mechanistic investigation of protein–peptide interactions and peptide therapeutics development. In this chapter, we describe the usage of our web server, referred to as ACCLUSTER, for peptide binding site prediction for a given protein structure. ACCLUSTER is freely available for users without registration at http://zougrouptoolkit.missouri.edu/accluster.