Total Synthesis of Jiadifenolide

Abstract

As a potent neurotrophic agent, the sesquiterpenoid jiadifenolide represents a valuable small‐molecule lead for the potential therapeutic treatment of neurodegenerative diseases. A stereocontrolled total synthesis of this densely functionalized natural product is reported, central to which is an adventurous samarium‐mediated cyclization reaction to establish the tricyclic core and the adjacent C5 and C6 quaternary stereocenters.