mSphere of Influence: Of Mice, Men, and Microbes—How Well Do Experimental Models Recapitulate Human Infection?

Abstract

Chelsie Armbruster studies catheter-associated urinary tract infection and the contribution of microbe-microbe interactions to infection progression and severity. In this mSphere of Influence article, she reflects on how two papers, A. Chelsie Armbruster studies catheter-associated urinary tract infection and the contribution of microbe-microbe interactions to infection progression and severity. In this mSphere of Influence article, she reflects on how two papers, A. E. Frick-Cheng, A. Sintsova, S. N. Smith, M. Krauthammer, et al., mBio 11:e01412-20, 2020, https://doi.org/10.1128/mBio.01412-20 , and D. M. Cornforth, F. L. Diggle, J. A. Melvin, J. M. Bomberger, and M. Whiteley, mBio 11:e03042-19, 2020, https://doi.org/10.1128/mBio.03042-19 , have impacted her thinking about the bacterial strains and experimental models used to study pathogenesis.