Background: There is growing interest in the nature of slow variations of the blood oxygen level-dependent (BOLD) signal observed in functional MRI resting-state studies. In humans. these slow BOLD variations are thought to reflect an underlying or intrinsic form of brain functional connectivity in discrete neuroanatomical systems. While these resting-state networks' maybe relatively enduring phenomena, other evidence suggest that dynamic changes in their functional connectivity may also emerge depending on the brain state subjects during scanning. Methodology/Principle Findings: In this study, we examined healthy subjects (n-24) with a mood induction paradigm during two continuous fMRI recording to assess the effects of a change in self-generated mood state (neutral to sad) on the networks that were common to both experimental states, each showing dominant signal fluctuation in the very low frequency domain (∼0.04 Hz). Between the two states, we observed apparent increases and decreases in the overall functional connectivity of these networks. Primary findings included increased connectivity strength of a paralimbic networks involving the dorsal anterior cingulate and anterior insula cortices with sunjects' increasing sadness and decreased functional connectivity of the 'default mode network. Conclusions/Significance: These findings support recent studies that suggest the functional connectivity of certain resting-state networks may in part, reflect a dynamic image of the current brain state. In our study, this was linked to changes in subjective mood. Copyright: © 2008 Harrison et al.
CITATION STYLE
Harrison, B. J., Pujol, J., Ortiz, H., Fornito, A., Pantelis, C., & Yücel, M. (2008). Modulation of brain resting-state networks by sad mood induction. PLoS ONE, 3(3). https://doi.org/10.1371/journal.pone.0001794
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