Elderly patients with single brain metastasis - Overall survival after surgery plus whole-brain irradiation and a radiation boost

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Abstract

Background/Aim: Elderly patients with a single brain metastasis likely benefit from personalized treatment protocols. To add to treatment personalization, a survival score was generated for these patients. Patients and Methods: This retrospective study included 36 elderly patients, each with a single brain metastasis, who received surgery followed by whole-brain irradiation and a radiation boost. Six pre-treatment characteristics were evaluated regarding survival, namely age, gender, Karnofsky performance score (KPS), type of primary tumor, noncerebral metastasis and interval from diagnosis of the neoplasm until surgery. Results: When applying the Cox regression model, KPS (p=0.005) and tumor type (p=0.018) were significant and incorporated in the score. Based on 12- month survival probabilities, three groups of 6-9 (n=5), 10- 11 (n=15) and 14-19 points (n=16) were formed, with 12- month survival rates of 0%, 33% and 100%, respectively (p<0.0001). Conclusion: A survival score was generated specifically for elderly patients with a single brain metastasis that can improve personalization of their treatment.

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Rades, D., Nguyen, T., & Schild, S. E. (2020). Elderly patients with single brain metastasis - Overall survival after surgery plus whole-brain irradiation and a radiation boost. In Vivo, 34(3), 1421–1425. https://doi.org/10.21873/invivo.11923

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