© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE). Optically derived tissue properties across a range of breast densities and the effects of breast compression on estimates of hemoglobin, oxygen metabolism, and water and lipid concentrations were obtained from a coregistered imaging system that integrates near-infrared spectral tomography (NIRST) with digital breast tomosynthesis (DBT). Image data were analyzed from 27 women who underwent four IRB approved NIRST/DBT exams that included fully and mildly compressed breast acquisitions in two projections - craniocaudal (CC) and mediolateral-oblique (MLO) - and generated four data sets per patient (full and moderate compression in CC and MLO views). Breast density was correlated with HbT (r=0.64, p=0.001), water (r=0.62, p=0.003), and lipid concentrations (r=-0.74, p<0.001), but not oxygen saturation. CC and MLO views were correlated for individual subjects and demonstrated no statistically significant differences in grouped analysis. Comparison of compressed and uncompressed imaging demonstrated a significant decrease in oxygen saturation under compression (58% versus 50%, p=0.04). Mammographic breast density categorization was correlated with measured optically derived properties.
CITATION STYLE
Michaelsen, K. E., Krishnaswamy, V., Shi, L., Vedantham, S., Karellas, A., Pogue, B. W., … Poplack, S. P. (2016). Effects of breast density and compression on normal breast tissue hemodynamics through breast tomosynthesis guided near-infrared spectral tomography. Journal of Biomedical Optics, 21(9), 091316. https://doi.org/10.1117/1.jbo.21.9.091316
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