GOLPH3 links the Golgi, DNA damage, and cancer

Abstract

GOLPH3 is the first example of an oncogene that functions in secretory traffi cking at the Golgi. The discovery of GOLPH3 ′ s roles in both cancer and Golgi trafficking raises questions about how GOLPH3 and the Golgi contribute to cancer. Our recent investigation of the regulation of GOLPH3 revealed a surprising response by the Golgi upon DNA damage that is mediated by DNA-PK and GOLPH3. These results provide new insight into the DNA damage response with important implications for understanding the cellular response to standard cancer therapeutic agents. -