Concentrações séricas de vitamina D e disfunção orgânica em pacientes com sepse grave e choque séptico

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Abstract

Objectives: To evaluate the serum concentrations of vitamin D and their variations in patients with severe sepsis or septic shock and in control subjects upon admission and after 7 days of hospitalization in the intensive care unit and to correlate these concentrations with the severity of organ dysfunction. Methods: This case-control, prospective, observational study involved patients aged > 18 years with severe sepsis or septic shock paired with a control group. Serum vitamin D concentrations were measured at inclusion (D0) and on the seventh day after inclusion (D7). Severe deficiency was defined as vitamin D levels < 10ng/ml, deficiency as levels between 10 and 20ng/ml, insufficiency as levels between 20 and 30ng/ml, and sufficiency as levels. 30ng/mL. We considered a change to a higher ranking, together with a 50% increase in the absolute concentration, to represent an improvement. Results: We included 51 patients (26 with septic shock and 25 controls). The prevalence of vitamin D concentration. 30ng/ml was 98%. There was no correlation between the serum concentration of vitamin D at D0 and the SOFA score at D0 or D7 either in the general population or in the group with septic shock. Patients with improvement in vitamin D deficiency had an improved SOFA score at D7 (p = 0.013). Conclusion: In the population studied, patients with septic shock showed improvement in the serum concentrations of vitamin D on the seventh day compared with the controls. We also found a correlation between higher vitamin D concentrations and a greater decrease in the severity of organ dysfunction.

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Alves, F. S., Freitas, F. G. R., Bafi, A. T., Azevedo, L. C. P., & Machado, F. R. (2015). Concentrações séricas de vitamina D e disfunção orgânica em pacientes com sepse grave e choque séptico. Revista Brasileira de Terapia Intensiva, 27(4), 376–382. https://doi.org/10.5935/0103-507X.20150063

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