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Journal ArticleOPEN ACCESS

Notch nicked again

  • Osherovich L
Science-Business eXchange (2011) 4(6) 151-151
DOI: 10.1038/scibx.2011.151
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Abstract

When preclinical studies suggested that broadly inhibiting the Notch pathway risked triggering tumors in epithelial tissue, Genentech and Aveo Pharmaceuticals tried to sidestep the potential adverse effects by selectively targeting NOTCH1. Now, a new paper has indicated that NOTCH1 inhibition itself may cause tumors.

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Osherovich, L. (2011). Notch nicked again. Science-Business EXchange, 4(6), 151–151. https://doi.org/10.1038/scibx.2011.151

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