Versatility of USP18 in physiology and pathophysiology

8Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

Abstract

Ubiquitin-specific peptidase 18 (USP18) is a multifunctional protein and its roles are still being investigated. This enzyme removes ubiquitin-like molecules from their substrates and the only known interferon-stimulated gene 15 (ISG15) specific protease. Apart from its enzymatic function, it also inhibits interferon type I and III signalling pathways. USP18 is known to regulate multiple processes, such as: cell cycle, cell signalling and response to viral and bacterial infections. Moreover, it contributes to the development of several autoimmune diseases and carcinogenesis, and recently was described as a cardiac remodelling inhibitor. This review summarizes the current knowledge on USP18 functions, highlighting its contribution to the development of heart failure, given the fact that this disease's etiology is now considered to be inflammatory in nature.

Cite

CITATION STYLE

APA

Dziamałek-Macioszczyk, P., Harazny, J. M., & Stompór, T. (2019). Versatility of USP18 in physiology and pathophysiology. Acta Biochimica Polonica. Acta Biochimica Polonica. https://doi.org/10.18388/ABP.2019_2844

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free