Assessment of immunogenicity and efficacy of a zika vaccine using modified vaccinia ankara virus as carriers

N/ACitations
Citations of this article
33Readers
Mendeley users who have this article in their library.

Abstract

Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that has spread to more than 70 countries worldwide since 2015. Despite active research, there are currently no licensed vaccines or therapeutics. We have previously reported the development of various adenoviral vectored vaccine candidates (ChAdOx1 ZIKV) with the ability to stimulate effective immunity in mice and provide protection upon a ZIKV challenge model, using a non-adjuvanted single vaccination approach. In this study, we constructed various modified vaccinia Ankara (MVA) viruses to express the ZIKV Envelope (E) with modifications on the precursor membrane (prM) or on the C-terminus envelope transmembrane domain (TM), similar to our ChAdOx1 vaccine candidates. MVA-ZIKV vaccine candidates were evaluated as a non-adjuvanted single vaccination regimen against a ZIKV Brazilian isolate, using viraemia as the correlate of protection. Here, we report the induction of a modest level of anti-ZIKV E antibodies by all MVA vectored vaccines and sub-optimal efficacy in a ZIKV challenge model. Our results indicate the requirement of additional strategies when using MVA-ZIKV vaccines to afford sterile protection upon a non-adjuvanted and single vaccination regime.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

López-Camacho, C., Kim, Y. C., Abbink, P., Larocca, R. A., Huiskonen, J. T., Barouch, D. H., & Reyes-Sandoval, A. (2019). Assessment of immunogenicity and efficacy of a zika vaccine using modified vaccinia ankara virus as carriers. Pathogens, 8(4). https://doi.org/10.3390/pathogens8040216

Readers over time

‘19‘20‘21‘22‘23‘24‘2505101520

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 17

77%

Researcher 4

18%

Lecturer / Post doc 1

5%

Readers' Discipline

Tooltip

Medicine and Dentistry 5

31%

Biochemistry, Genetics and Molecular Bi... 4

25%

Immunology and Microbiology 4

25%

Agricultural and Biological Sciences 3

19%

Article Metrics

Tooltip
Social Media
Shares, Likes & Comments: 59

Save time finding and organizing research with Mendeley

Sign up for free
0