Hepamerz treatment of hepatic encephalopathy

Abstract

A course of hepamerz treatment (7 intravenous drip infusions followed by oral administration for 14 days) was tried in 14 patients with hepatic cirrhosis to clarify hepamerz effects on hepatic encephalopathy and hyperammoniemia which were judged by blood ammonium levels and time of psychomotor tests. All the patients responded. Fasting ammonium levels reduced in 67%, after meal in 82% of patients. 68% improved their psychomotor parameters. Transient nausea as a side effect occurred in 3 patients.