Assays profiling nucleosome positioning and occupancy are often coupled with high-throughput sequencing, which results in generation of large data sets. These data sets require processing in specialized computational pipelines to yield useful information. Here, we describe main steps of such a pipeline, and discuss bioinformatic and statistical aspects of assessing data quality, as well as data visualization and further analysis.
CITATION STYLE
Mieczkowski, J., & Tolstorukov, M. Y. (2018). Bioinformatic Analysis of Nucleosome and Histone Variant Positioning. In Methods in Molecular Biology (Vol. 1832, pp. 185–203). Humana Press Inc. https://doi.org/10.1007/978-1-4939-8663-7_10
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