Hemerythrin is proposed as an alternative to hemoglobin-based blood substitutes. In contrast to hemoglobin, hemerythrin exhibits negligible reactivity towards oxidative and nitrosative stress agents (peroxide, nitric oxide, nitrite). Protocols for attachment of polyethylene glycol and glutaraldehyde cross-linking of Hr are described. These derivatizations appear to have favorable effects on O2 affinity and autoxidation rates for use in blood substitutes. Based on lessons learned from hemoglobin-based blood substitutes, these derivatizations should also help limit extravasation and antigenicity of a hemerythrin-based blood substitute. © 2010 Springer Science+Business Media, LLC.
CITATION STYLE
Mot, A. C., Roman, A., Lupan, I., Kurtz, D. M., & Silaghi-Dumitrescu, R. (2010). Towards the development of hemerythrin-based blood substitutes. Protein Journal, 29(6), 387–393. https://doi.org/10.1007/s10930-010-9264-2
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