Bridging the b cell gap: Novel technologies to study antigen-specific human b cell responses

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Abstract

The generation of high affinity antibodies is a crucial aspect of immunity induced by vaccination or infection. Investigation into the B cells that produce these antibodies grants key insights into the effectiveness of novel immunogens to induce a lasting protective response against endemic or pandemic pathogens, such as influenza viruses, human immunodeficiency virus, or severe acute respiratory syndrome coronavirus-2. However, humoral immunity has largely been studied at the serological level, limiting our knowledge on the specificity and function of B cells recruited to respond to pathogens. In this review, we cover a number of recent innovations in the field that have increased our ability to connect B cell function to the B cell repertoire and antigen specificity. Moreover, we will highlight recent advances in the development of both ex vivo and in vivo models to study human B cell responses. Together, the technologies highlighted in this review can be used to help design and validate new vaccine designs and platforms.

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Utset, H. A., Guthmiller, J. J., & Wilson, P. C. (2021, July 1). Bridging the b cell gap: Novel technologies to study antigen-specific human b cell responses. Vaccines. MDPI. https://doi.org/10.3390/vaccines9070711

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