LDOC1 Gene Expression in Men With Klinefelter Syndrome

2Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Klinefelter syndrome (KS) results from an extra chromosome X, which is due to the failure of normal chromosomal segregation during meiosis. Patients with KS have gynecomastia, small testes, and azoospermia. Apoptosis is a mechanism responsible for the normal regulation of spermatogenesis. LDOC1 gene is a known regulator of nuclear factor mediated pathway to apoptosis through inhibition of nuclear factor kappa B (NF-kappaB). Furthermore, the transcription factor myeloid zinc finger gene 1 (MZF-1) has been shown to interact with LDOC1 and to enhance LDOC1 activity favoring apoptosis. We investigated the expression of LDOC1 gene mRNA, by quantitative reverse transcription polymerase chain reaction (qRT-PCR), in peripheral blood leukocytes of 13 patients with KS compared to 13 healthy men chosen as controls. LDOC1 expression was higher in 9 of the 13 KS patient compared to normal controls. These finding led us to hypothesize that LDOC1 gene upregulation may play a role in the spermatogenesis derangement observed in patients with KS.

References Powered by Scopus

Analysis of relative gene expression data using real-time quantitative PCR and the 2<sup>-ΔΔC</sup>T method

149922Citations
N/AReaders
Get full text

Prenatal and postnatal prevalence of Klinefelter syndrome: A national registry study

737Citations
N/AReaders
Get full text

Syndrome characterized by gynecomastia, aspermatogenesis without a-leydigism, and increased excretion of follicle-stimulating hormone

687Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Modeling Klinefelter Syndrome Using Induced Pluripotent Stem Cells Reveals Impaired Germ Cell Differentiation

8Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Salemi, M., Condorelli, R. A., Longo, G., Bullara, V., Romano, C., Campagna, C., … Calogero, A. E. (2016). LDOC1 Gene Expression in Men With Klinefelter Syndrome. Journal of Clinical Laboratory Analysis, 30(5), 408–410. https://doi.org/10.1002/jcla.21870

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 5

56%

Professor / Associate Prof. 2

22%

Researcher 2

22%

Readers' Discipline

Tooltip

Medicine and Dentistry 4

40%

Biochemistry, Genetics and Molecular Bi... 3

30%

Nursing and Health Professions 2

20%

Psychology 1

10%

Save time finding and organizing research with Mendeley

Sign up for free