Here we report the synthesis of a novel methylene blue-polymyxin conjugate and demonstrate its light-mediated killing of Gram-negative bacteria on skin models of infection demonstrating a 108 decrease in bacterial colony-forming units.
CITATION STYLE
Ucuncu, M., Mills, B., Duncan, S., Staderini, M., Dhaliwal, K., & Bradley, M. (2020). Polymyxin-based photosensitizer for the potent and selective killing of Gram-negative bacteria. Chemical Communications, 56(26), 3757–3760. https://doi.org/10.1039/d0cc00155d
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