Abstract
Neutrophil extracellular traps (NETs) contribute to immunothrombosis and have been associated with mortality in coronavirus disease 2019 (COVID-19). We stimulated donor neutrophils with plasma from patients with COVID-19 and demonstrated that R406 can abrogate the release of NETs. These data provide evidence for how fostamatinib may mitigate neutrophil-associated mechanisms contributing to COVID-19 immunopathogenesis.
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Strich, J. R., Ramos-Benitez, M. J., Randazzo, D., Stein, S. R., Babyak, A., Davey, R. T., … Chertow, D. S. (2021). Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic. Journal of Infectious Diseases, 223(6), 981–984. https://doi.org/10.1093/infdis/jiaa789
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