A comparison of macrophage migration inhibitory factor with C reactive protein in diabetic hypertensive patients with myocardial infarction that underwent primary percutaneous coronary intervention

Abstract

The inflammatory response is one of the complications of diabetic hypertensive patients with myocardial infarction (MI). The purpose of this study was to determine the diagnostic value of macrophage migration inhibi-tory factor (MIF) compared with high sensitivity C reactive protein (hs-CRP) in diabetic hypertensive patients presented with MI; and to determine the con-comitant association between these factors in MI patients. For this purpose, 100 patients with MI were categorized into four groups, according to the exis-tence of diabetes mellitus (DM) and/or hypertension (HTN), with 38 subjects with normal angiography considered as the control group. The levels of MIF and hs-CRP were estimated quantitatively using a sandwich enzyme-linked immu-nosorbent assay and a particle-enhanced immune turbidimetric assay, respec-tively. In addition, lipid profiles, hematological indicators, and certain clinical features were compared among the studied groups. The levels of MIF and hs-CRP increased significantly in MI patients compared to the controls (p<0.05). Additionally, the levels of MIF differed significantly between all MI groups and the control group (p<0.05). Although the group DM-HTN showed the highest MIF level within the MI groups, the difference was not significant (p>0.05). However, the hs-CRP level showed a significant difference (p<0.05). In addi-tion, the MIF level correlated positively with hs-CRP, leukocytes, and neutro-phils (p<0.05). Both MIF and hs-CRP levels correlated positively with age, body mass index (BMI), total cholesterol, triglyceride, low-density lipoprotein-cho-lesterol (LDL-C) and non-high density lipoprotein (HDL), but they correlated negatively with HDL-C. According to the results, although MIF was a valuable diagnostic marker for MI, the hs-CRP showed to be a better prognostic indica-tor than MIF in diabetic hypertensive patients that presented MI.