Heparan sulfate 2-O-sulfotransferase (HS2ST)

Abstract

Backbone structure of heparan sulfate (HS) and heparin is composed of HexA-GlcNAc/GlcNSO3 repeating units, in which HexA is either D-GlcA or l-IdoA, linked to core proteins through a tetrasaccharide linkage sequence, GlcA-Gal-Gal-Xyl. Sulfate groups are present on the position 2 of the HexA, position 3 and 6 of the GlcNAc/GlcNSO3, and position 2 in the GlcNSO3. Heparan sulfate 2-O-sulfotransferase (HS2ST) transfers sulfate from 3′-phosphoadenosine 5′-phosphosulfate (PAPS) to position 2 of the IdoA and GlcA residue in HS and heparin.