Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion

44Citations
Citations of this article
49Readers
Mendeley users who have this article in their library.

Abstract

Malignant pleural mesothelioma is a poorly treated neoplasia arising from the pleural mesothelial lining. Here we document that the leaf extract of Cynara scolymus exerts broad antitumoral effects both in vitro and in vivo on mesothelioma cell lines. We found that Cynara scolymus treatment affects strongly cell growth, migration and tumor engraftment of mesothelioma cell lines. Strikingly, dietary feeding with Cynara scolymus leaf extract reduces the growth of mesothelioma xenografted tumors similarly to pemetrexed, a commonly employed drug in the treatment of mesothelioma. In aggregate our findings suggest that leaf extract of Cynara scolymus holds therapeutic potential for the treatment of mesothelioma.

Cite

CITATION STYLE

APA

Pulito, C., Mori, F., Sacconi, A., Casadei, L., Ferraiuolo, M., Valerio, M. C., … Strano, S. (2015). Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion. Oncotarget, 6(20), 18134–18150. https://doi.org/10.18632/oncotarget.4017

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free