Fluvirucins A1 A2, B1, B2, B3, B4 and B5, new antibiotics active against influenza a virus: I. production, isolation, chemical properties and biological activities

Abstract

Five unidentified actinomycete strains produced a series of novel antiviral antibiotics which have a unique 2,6-dialkyl-10-ethyl-3(or 9)-hydroxy-13-tridecanelactam nucleus substituted with 3-amino-3,6-dideoxy-l-talose or 3-amino-3,6-dideoxy-l-mannose(l-mycosamine). The antibiotic components exhibited potent inhibitory activity against influenza virus type A Victoria strain infection in Madin Darby canine kidney cells by the cytopathic effect reduction assay. © 1991, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.