Preoperative prediction of tumor budding in rectal cancer using multiple machine learning algorithms based on MRI T2WI radiomics

Abstract

Objective: This study aimed to explore the radiomics model based on magnetic resonance imaging (MRI) T2WI and compare the value of different machine algorithms in preoperatively predicting tumor budding (TB) grading in rectal cancer. Methods: A retrospective study was conducted on 266 patients with preoperative rectal MRI examinations, who underwent complete surgical resection and confirmed pathological diagnosis of rectal cancer. Among them, patients from Qingdao West Coast Hospital were assigned as the training group (n=172), while patients from other hospitals were assigned as the external validation group (n=94). Regions of interest (ROIs) were delineated, and image features were extracted and dimensionally reduced using the Least Absolute Shrinkage and Selection Operator (LASSO). Eight machine algorithms were used to construct the models, and the diagnostic performance of the models was evaluated and compared using receiver operating characteristic (ROC) curves and the area under the curve (AUC), as well as clinical utility assessment using decision curve analysis (DCA). Results: A total of 1197 features were extracted, and after feature selection and dimension reduction, 11 image features related to TB grading were obtained. Among the eight algorithm models, the support vector machine (SVM) algorithm achieved the best diagnostic performance, with accuracy, sensitivity, and specificity of 0.826, 0.949, and 0.723 in the training group, and 0.713, 0.579, and 0.804 in the validation group, respectively. DCA demonstrated the clinical utility of this radiomics model. Conclusion: The radiomics model based on MR T2WI can provide an effective and noninvasive method for preoperative TB grading assessment in patients with rectal cancer.