Phospholipases are a family of lipid-altering enzymes that can either reduce or increase bioactive lipid levels. Bioactive lipids elicit signaling responses, activate transcription factors, promote G-coupled-protein activity, and modulate membrane fluidity, which mediates cellular function. Phospholipases and the bioactive lipids they produce are important regulators of immune cell activity, dictating both pro-inflammatory and pro-resolving activity. During atherosclerosis, pro-inflammatory and pro-resolving activities govern atherosclerosis progression and regression, respectively. This review will look at the interface of phospholipase activity, immune cell function, and atherosclerosis.
CITATION STYLE
Schilke, R. M., Blackburn, C. M. R., Bamgbose, T. T., & Woolard, M. D. (2020, October 1). Interface of phospholipase activity, immune cell function, and atherosclerosis. Biomolecules. MDPI AG. https://doi.org/10.3390/biom10101449
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