Temporal trends in death causes in adults attending an urban HIV clinic in Uganda: A retrospective chart review

Abstract

Objective: To study temporal trends of mortality in HIV-infected adults who attended an HIV clinic in Kampala, Uganda, between 2002 and 2012. Design: Descriptive retrospective study. Methods: Two doctors independently reviewed the clinic database that contained information derived from the clinic files and assigned one or more causes of death to each patient >18 years of age with a known date of death. Four cause-of-death categories were defined: communicable conditions and AIDS-defining malignancies , chronic non-communicable conditions , other non-communicable conditions and unknown . Trends in cause-of-death categories over time were evaluated using multinomial logistic regression with year of death as an independent continuous variable. Results: 1028 deaths were included; 38% of these individuals were on antiretroviral therapy (ART). The estimated mortality rate dropped from 21.86 deaths/ 100 person years of follow-up (PYFU) in 2002 to 1.75/ 100 PYFU in 2012. There was a significant change in causes of death over time ( p<0.01). Between 2002 and 2012, the proportion of deaths due to communicable conditions and AIDS-defining malignancies decreased from 84% (95% CI 74% to 90%) to 64% (95% CI 53% to 74%) and the proportion of deaths due to chronic non-communicable conditions , other noncommunicable conditions and a combination of communicable and non-communicable conditions increased. Tuberculosis (TB) was the main cause of death (34%). Death from TB decreased over time, from 43% (95% CI 32% to 53%) in 2002 to a steady proportion of approximately 25% from 2006 onwards (p<0.01). Conclusions: Mortality rate decreased over time. The proportion of deaths from communicable conditions and AIDS-defining malignancies decreased and from non-communicable diseases, both chronic and nonchronic, increased. Nevertheless, communicable conditions and AIDS-defining malignancies continued to cause the majority of deaths, with TB as the main cause. Ongoing monitoring of cause of death is warranted and strategies to decrease mortality from TB and other common opportunistic infections are essential.